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Surface properties of natural, purified and doped crystalline silicas and cellular responses upon ce |
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Mara Ghiazza (2002-2005) PhD in Bio-Chemical Science
It is generally accepted that the variability of crystalline silica hazard stems from differences in surface properties among the various dust sources. However, the extent at which a given surface property governs the biological response elicited, is still a matter of debate. A tentative assignment of the various physico-chemical properties to the subsequent events taking place in the lung following the deposition of a quartz particle, in the alveolar space has been proposed (Fubini, 1998b; Fenoglio et al., 2000; Fubini et al., 2001; Fubini and Hubbard, 2003).
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Asbestos hazard in Western Alps: mineral burden investigation to assess the environmental exposure |
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Elisa Fornero (2002-2005) PhD in Geological Sciences
A particle with one dimension much bigger than the others is defined “fibre”. Many minerals have this kind of habit and are defined “fibrous”. Asbestos is the most known group of fibrous minerals having in common the following chemical and physical characteristics: can be separated into long, thin, strong fibres and have sufficient flexibility to be woven; are heat resistant, chemically inert and electrical insulators (Veblen & Wylie, 1993).
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Asbestos hazard in western Alps: petrology of asbestos-bearing serpentinites of western Alps |
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Chiara Groppo (2002-2005) PhD in Geological Sciences
Asbestos hazard in western Alps: petrology, characterization and quantitative determination of fibrous minerals in the asbestos-bearing serpentinites of the Piemonte Zone (Susa and Lanzo valleys)
The word "asbestos", that means unquenchable, is used for a group of silicate minerals occurring with a fibrous habit, belonging to the serpentine and amphibole families. According to the Italian Legislation (D.L. 15/08/91) the six fibrous silicates defined as asbestos are: chrysotile, amosite and crocidolite (fibrous varieties of grunerite and riebeckite, respectively), anthophyllite, tremolite and actinolite. These minerals are made up of incombustible, chemically stable, inert, phono-absorbing, flexible and tensile fibers.
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Toxicity-related physico-chemical properties of carbon nanotubes (CNTs) and nanometric titanium dioxides |
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Giovanna Greco (2005-2008) PhD in Bio-Chemical Sciences
Over the last two decades, there has been a very rapid implementation of nanotechnologies, which find practical applications in many fields of industry and daily life. Bio-nanotechnology and nanomedicine are dynamically developing fields of scientific interest and nanoparticles are studied as drug delivery systems in order to increase drug effectivness and limit the side effects.
Concerns about human and environmental exposures resulting in potential adverse effects have increased as well. Carbon nanotubes (CNTs) have been reported to elicit toxic responses both in vitro and in vivo, ascribed so far to metal contamination, CNT length, degree of oxidation, or extent of hydrophilicity.
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Study of the interaction between serum proteins and variously modified crystalline silicas |
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Federico Gillio (2002-2005) PhD in Bio-Chemical Science
The interaction of proteins with the surface of quartz particles may involve different phenomena: the adsorption of the proteins at the surface of the particles, the modification of the proteins conformation, the oxidative damage of the protein mediated by free radicals generated at the surface of quartz and the modification of the quartz surface itself.
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Role of metal component in the potential toxicity of composite materials |
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Ingrid Corazzari (2005-2008) Ph.D in Bio-Chemical Sciences
Different forms of pulmonary diseases have been described among workers exposed to hard metals. Hard metal are made of a mixture of tungsten carbide particles cemented in cobalt metal powder. Workers exposed to hard metal dusts can develop some pulmonary diseases such as asthma and a form of interstitial fibrosis known as "hard metal lung disease".
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Asbestos hazard in Western Alps: fungi for bioremediation |
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Stefania Daghino (2002-2005) Ph.D. in Biology and Biotechnology of Fungi
Serpentine soils, derived from the weathering of ultramafic rocks (i.e. rock high in iron and magnesium silicates) offer environmental cases for the study of the interaction mineral/fungi or metal/fungi. Such soils have strong limitations of fertility because of their mineral composition, rich in magnesium and containing heavy metals that reach hazard levels, such as nickel and chromium. In Italy, serpentine sites are found in the North-Western Alps and in the Northern Appenin, and they are considered to be a source of biological variability and biodiversity. Serpentine rocks can bear asbestos minerals, which represent a hazard for health if exposed, airborne and inhaled.
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Asbestos hazard in western Alps: lichens bioremediation |
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Sergio E. Favero Longo (2002-2005) Ph.D. in Biology and Biotechnology of Fungi
Lichens for bioremediation: an ecological, microbiological and chemical analysis on vegetal and fungal interactions with serpentine substrata. The case of the Balangero and Corio disused asbestos mine (Torino, Italy).
Since the end of XIX century, the interface between lichens and rocks has been recognized and examined as a place of considerable physical and chemical activity where weathering and pedogenesis processes develop (Syers and Iskandar, 1973). A biological and mineralogical multidisciplinary approach was widely adopted during the last century in order to evaluate the multiple aspects implicated in the interaction between the biotic and the abiotic components (Adamo and Violante, 2000).
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